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In the Cubist case, Hospiras invalidity arguments had survived early stages of the case, which should have produced a meaningful probability weight on the adverse scenario well above 20-30%

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This could potentially be explained by the greater levels of semaglutide exposure as a result of the lower mean baseline body weight in PIONEER 12 than in PIONEER 3 (79.5 kg vs 91.2 kg) [18, 25]